“Non Line Of Sight” is an ultra long-range version of the weapon (Israeli designation: Tamuz, תמוז), with a claimed maximum range of 32 km (20 mi). It is a significantly larger missile than other Spike variants, with an overall weight of around 70 kg (150 lb). It can be launched from the ground or from helicopters. It was developed following lessons learned in the Yom Kippur War, which showed a need for a high-precision guided tactical ground-to-ground battlefield missile. The first variants entered service with the Israel Defense Forces (IDF) in tandem with the Pereh missile carrier in 1981, though the existence of both was not revealed to the public until 2011. The Spike NLOS uses a fiber optic link similar to other Spike versions, but only out to 8 km, after which it employs a radio data link for command guidance.

In 2011 it also became known that in a highly unusual move, the British Army was hastily equipped with the missile for counter-mortar fire, drawn directly from IDF inventory after being exposed to increasing insurgent attacks in Iraq. Beginning in 2007 three variants of the NLOS were procured. A total of 600 missiles were acquired, the breakdown being 200 optical camera equipped NLOS Mk.2 in 2007, 200 thermal imaging equipped NLOS Mk.4 in 2008 for night operations (together with the NLOS Mk.2 these were known as EXACTOR-1), 200 dual camera equipped NLOS Mk.5 (EXACTOR-2) followed in 2009 which featured wings for slower but better maneuvering flight and a multi-purpose warhead replacing the anti-armor warhead of previous versions. For operational security, the codename of 'EXACTOR missile' was assigned in British service and it was initially mounted on launchers atop leased M113 APCs. The NLOS Mk.2 performed badly being too fast and difficult to control, the M113 overheated in the desert and had a poor resolution camera display that compared unfavorably with its contemporaries. So Britain financed the development of the NLOS Mk.5 known in British service as the EXACTOR 2 which replaced the M113 APC with a towed trailer known as SPARC holding four missiles in a 360-degree rotating turret that could be remotely controlled up to 500 m away ditching the non-standard M113 APCs altogether when in 2010 the batteries were transferred from Iraq to Afghanistan.

In a deal concluded on 6 September 2011, the South Korean government had agreed to purchase an unknown number of Spike NLOS Mk.5 missiles.